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May 8, 2014


Experts predict that by 2050 the occurrence of Alzheimer’s in the U.S. and elsewhere will triple.1 Did you know that almost two-thirds of Americans with Alzheimer’s are women?2  These are scary statistics. The question is can you do anything to reduce your chances of becoming its victim?  

I believe you can.  

Hormones Are Your Best Friends 

A synergetic relationship exists between every process, every hormone, and every organ, gland and cell in your body. Disrupt any of it, especially the production of hormones, and the internal disorder creates an inviting environment for health problems. This is true whether the cause lies in the aging process, genetic predisposition, illness or a surgical procedure. 

For decades now, I’ve been treating hormone deficient women with bioidentical hormone replacement therapy (BHRT). I’ve witnessed time and again what hormone restoration can do. I believe it is critical to your health to restore key hormones – testosterone and estrogen (specifically estradiol) – to beneficial levels. Your body needs them to work properly. Every day I see the remarkable difference this makes in quality of life and well-being. In fact, my wife and I are living proof of how well proper hormone replacement works. We’ve been SottoPelle® Therapy patients ourselves for 15 years! 

I especially encourage reestablishing normal estradiol levels in women. It is a vital step in reducing the risk of dementia and Alzheimer’s. And this isn’t just one random opinion. Today’s scientific research continues to reveal strong evidence that estradiol is essential to proper brain function.   

Menopause Is All About Hormone Deficiency 

Bottom line: balanced hormones are vital to good health. Unfortunately, nature doesn’t provide for that kind of lifelong internal stability.  

Typically, you reach your 40s and the body’s hormone production slows, eventually coming to a halt. That’s when we say menopause has occurred. During the time prior to menopause (called peri-menopause) hormone levels fluctuate wildly.  This results in a crazy roller-coaster ride of hormonal imbalance, a circumstance that commonly brings on an array of symptoms. Most female patients come to me suffering from hot flashes, night sweats, painful intercourse, weight gain, sleeplessness and other physical issues. They also reveal equally concerning problems like fuzzy thinking, memory lapses, foggy brain, and cognitive difficulties. These can be brutally debilitating as well.  

When your ovaries stop working and hormone production ends, as it does in menopause, it can leave you depleted, feeling exhausted, cross and completely unlike the person you once were. It’s a time of internal imbalance. Nonetheless, your adrenal glands and fat cells try to take over, attempting to restore what once was. They continue to create sex hormones in miniscule amounts—with the exception of estradiol.  The creation of estradiol (your most important estrogen) ceases altogether. That’s when you develop the symptoms and problems I previously mentioned. With those come the potential for many aging-related diseases, including Alzheimer’s. 

The Estradiol/Brain Connection 

The human brain is rich with estrogen receptors, especially in the regions where the process of learning new information, holding onto it and using it are located making estradiol critical to memory and cognitive ability. It is also widely accepted that it affects fine motor control, pain perception and mood. 

Estradiol serves both protective and supportive roles in the survival, development and function of neurons located there. It counteracts the harmful effects of free radicals, protects the brain from certain injuries, and defends it against the damage of amyloid protein—which is toxic to brain neurons and significantly present in Alzheimer’s disease.  

Estradiol also plays a key role in the production of serotonin, dopamine and norepinephrine. These substances influence mental conditions such as alertness, energy, mood, attention, motivation and pleasure, among others. Additionally, we know that estradiol positively impacts blood flow, which the brain depends on, and serves as an anti-inflammatory, to a large degree preventing damage to artery walls.  

The Strong Case for Restoring Hormones  

Currently, substantial research is centered on the positive estradiol effect on cognition and subsequent Alzheimer’s disease prevention.3 One very significant finding shows that reduced estradiol in the menopausal brain also reduces the presence of an important enzyme that facilitates the disposal of beta-amyloid, a key factor in Alzheimer’s.4 In facing the current and worsening crisis of this disease, scientists agree that further research needs to be done in order to fully address the issue of prevention.  

All of this falls in line with my own observations during many years of administering BHRT to women. Complex as the human body is, it never ceases to amaze me how responsive it is to getting what it needs. Patients report to me that their physical symptoms and brain glitches generally disappear. If not, we continue to adjust hormone dosages until we have it right. I’ve also observed that certain health issues improve and some even resolve themselves over time.  Afflictions such as osteoporosis, cardio-vascular problems, diabetes and even Parkinson’s and Traumatic Brain Injury (TBI) repeatedly appear to respond positively to beneficial levels of testosterone and estradiol. 

Have Your Hormones Tested! 

 If you are 40 or over, I urge you to have your hormone levels tested. I know for a fact that a science-based BHRT such as SottoPelle®, that is properly administered and monitored by an expert, can go a long way in providing a healthier future for you.  








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